Background: The biological profile of HIV-positive patients is essential for\ndiagnosing treatment failure and the prognosis of infection. We determined\nthe virological and immunological profiles and biological anomalies of\nHIV-positive people on antiretroviral therapy (ART) in Bangui, Central African\nRepublic. Methods: We conducted an analytical, descriptive study between\n4 April and 30 September 2017 of all patients who had received ART\nfor more than 12 months and who attended the Medical Analysis Laboratory\nof the Institut Pasteur in Bangui for a complete biological work-up, including\nviral load. A blood sample was taken for quantification of RNA HIV-1, CD4\nlymphocytes and blood count in two tubes containing ethylenediamine tetraacetic\nacid, and another sample was taken in a dry tube for measurement of\ncreatinine and transaminases. Results: The total population comprised 1748\npatients, with a mean age of 38.7 years (�±14.3; median, 41 years; range, 2 - 79\nyears); 33.3% of patients were between 40 and 49 years old. Females predominated\n(71.3%), for a sex ratio of 0.4. Immunological failure was observed in\n20.2% of patients (CD4 < 200 cells/�¼L), and 44.5% of patients had a load of\nRNA HIV-1 â�¥ 1000 copies/mL. The main haematological anomalies were\nanaemia (28.0%), leukopenia (26.7%), neutropenia (42.1%) and lymphopenia\n(27.2%). Blood creatinine was abnormal in 61.0% of patients, ALAT in 57.0%\nand ASAT in 66.9%. Conclusion: The abnormalities observed in this study\nconcerned the haematopoietic system, the liver and the kidneys. As other organs\nand systems may be affected, periodic multidisciplinary biological and\nclinical follow-up is necessary for people living with HIV in order to improve\ntheir management.
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